Neuroscience, Diseases & Related Sciences Symposium

神经科学及其交叉学科前沿系列研讨会

Glial cells and neurological diseases

April 23, 2026 | Guangzhou Bio-Island

Center for Medical Research on Innovation & Translation, Guangzhou First People's Hospital, an Affiliated Hospital of South China University of Technology and Guangzhou Medical University

广州市第一人民医院
华南理工大学附属第二医院

主办方：
广州市第一人民医院医学研究与创新转化中心
广州市第一人民医院神经免疫与健康实验室(LNHD.org)
广州市第一人民医院徕卡显微系统共建实验室

Syposium overview：The Neuroscience, Diseases & Related Sciences Symposium of Guangzhou First People's Hospital aims to explore global frontiers and research methodologies in both clinical and basic neuroscience as well as related fields. The symposium seeks to promote the development of neuroscience and its interdisciplinary branches.

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○ 15:00 What triggers (early) astrocyte reactivity?
黄文辉 中山大学孙逸仙纪念医院

BIO: 副研究员，博士生导师，入选中山大学“百人计划”中青年杰出人才项目。先后在德国汉堡大学，马克思普朗克实验医学研究所以及萨尔大学学习、工作。师从胶质细胞领域著名学者Frank Kirchhoff教授，归国前任萨尔大学分子生理学系独立PI。2025年作为中山大学“百人计划”引进人才加入孙逸仙纪念医院脑科学中心。研究方向与成果：长期专注于神经胶质细胞的发育、异质性以及功能的研究，目前聚焦在以下两方面：1、少突胶质细胞前体细胞 (又称NG2 glia)的发育与功能；2、神经胶质细胞对神经炎症的调控机制。相关成果以第一/通讯作者身份在Nat Commun、Glia、Acta Neuropathol Commun、J Neurochem等杂志发表。近年来主持来自德国科学基金会 （DFG，2项）、德国Fritz Thyssen基金会、中德科学中心、萨尔大学杰出青年基金等机构的多项研究基金项目。

报告简介: 在神经系统疾病中，病理反应性星型胶质细胞常被认为是激活的小胶质细胞的效应细胞。近期研究发现星型胶质细胞也可迅速对病理刺激做出反应，但该反应性的触发机制及功能并不明确。主讲人将介绍他们在败血症相关脑病以及急性脑损伤中腺苷信号调控星形胶质细胞反应性方面的研究进展。

○ 15:45 The Trem2–Gpnmb Axis Across Stroke and Alzheimer’s Disease
项贤媛 深圳理工大学 生命健康学院

BIO: 教研助理教授/科研副教授、博士生导师。研究方向为小胶质细胞的生理及病理功能。实验室主要以小鼠及人类诱导性多功能干细胞（iPSC）分化模型，从免疫的角度阐明不同神经系统疾病的共性与特异性分子机制，鉴定调节大脑免疫功能的干预靶点。研究成果以第一作者或共同通讯作者发表在PNAS, GLIA, Science Translational Medicine, EMBO Molecular Medicine, Molecular Neurodegeneration等国际知名期刊。主持多项科研项目包括国自然青年C项目、国自然面上项目，深圳市优秀青年项目，深圳医学科学院青年提升项目等。

报告简介: Microglia respond rapidly to brain injury, yet the signaling pathways that determine whether these responses are protective or detrimental remain incompletely understood. In this talk, I will discuss recent work identifying the Trem2–Gpnmb axis as a key regulator of microglial function across distinct neurological disorders. Using a photothrombotic stroke model, we found that Trem2 exacerbates ischemic brain injury through Gpnmb-dependent mechanisms, linking microglial activation to worsened tissue damage and neurological outcome. I will then extend this framework to Alzheimer’s disease, where our work suggests that Gpnmb is not merely a marker of disease-associated microglia, but an active modulator of microglial phenotype and pathological progression. By comparing stroke and Alzheimer’s disease, this presentation will highlight how the Trem2–Gpnmb pathway may represent a shared molecular program through which microglia interpret injury and neurodegeneration.

○ 16:30 小胶质细胞的成像与神经退行性疾病
刘勇 广州市第一人民医院 临床医学研究所

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主办方：
广州市第一人民医院神经免疫与健康实验室(LNHD.org)
广州市第一人民医院徕卡显微系统共建实验室
广州市第一人民医院（华南理工大学附属第二医院） 医学研究与创新转化中心

地址：生物岛寰宇二路10号B栋9楼

交通指引：【会场定位】导航至“生物岛寰宇二路10号B栋”，从B栋一楼大门进入。

自驾指引：【停车场入口定位】导航至“广州国际生物岛园区-南区”前行5米右转进停车场负一楼，下坡后左转后右转，直行到底进入B区后停车，B栋电梯厅在前行方向左前方。